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#1 of 9 Old 03-20-2002, 10:16 PM - Thead Starter
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All About Domperidone
By Dr. Jack Newman MD, FRCPC



Introduction
Domperidone (Motilium™) is a drug which has, as a side effect, the increased production of the hormone prolactin. Prolactin is the hormone which stimulates the cells in the mother's breast to produce milk. Domperidone increases prolactin secretion indirectly, by interfering with the action of dopamine. One of the actions of dopamine is that it decreases the secretion of prolactin by the pituitary gland. Domperidone is generally used for disorders of the gastrointestinal tract (gut) and has not been released in Canada for use as a stimulant for milk production. This does not mean that it cannot be prescribed for this reason, but rather that the manufacturer does not back its use for increasing milk production. It has been used, for several years, in small infants who spit up and lose weight, but it has recently been replaced for this reason by a newer drug called cisapride (Prepulsid™).

Domperidone's ability to increase milk production has been recognized since it first became available. Another, related, but older medication, metoclopramide (Maxeran™), is also known to increase milk production, but it has frequent side effects which have made its use for many nursing mothers unacceptable (fatigue, irritability, depression). Domperidone has many fewer side effects because it does not enter the brain tissue in significant amounts (does not pass the blood-brain barrier).

When is it appropriate to use domperidone?
Domperidone must never be used as the first approach to correcting breastfeeding difficulties. Domperidone is not a cure for all things. It must not be used unless all other factors which may result in insufficient milk supply have been dealt with first. These include:
1. correcting the baby's latch so that the baby can obtain as efficiently as possible the milk which the mother has available. Correcting the latch may be all that is necessary to change a situation of "not enough milk" to one of "plenty of milk."
2. using breast compression to increase the intake of milk (see Breast Compression).
3. using milk expression after feedings to increase the supply.
4. correcting sucking problems, stopping the use of artificial nipples (see Using a Lactation Aid, and Finger Feeding) and other stratagems.

Using domperidone for increasing milk production
Domperidone works particularly well to increase milk production under the following circumstances:

It has frequently been noted that a mother who is pumping milk for a sick or premature baby in hospital has a decrease in the amount she pumps around 4 or 5 weeks after the baby is born. The reasons for this are likely many, but domperidone generally brings the amount of milk pumped back to where it was or even to higher levels.
When a mother has a decrease in milk supply, often associated with the use of birth control pills (avoid estrogen containing birth control pills while breastfeeding), or on occasion for no obvious reason when the baby is 3 or 4 months old, domperidone will often bring the supply back to normal.
Domperidone still works, but often less dramatically when:

The mother is pumping for a sick or premature baby but has not managed to develop a full milk supply.
The mother is trying to develop a full milk supply while nursing an adopted baby.
The mother is trying to wean the baby from supplements.
Side effects of domperidone
As with all medications, side effects are possible, and many have been reported with domperidone (textbooks often list any side effect ever reported, but symptoms reported are not necessarily due to the drug a person is taking). There is no such thing as a 100% safe drug. However, our clinical experience has been that side effects in the mother are extremely uncommon, except for increasing milk supply. Some side effects which mothers we have treated have reported (very uncommonly, incidentally):

dry mouth
headache which disappeared when the dose was reduced
abdominal cramps
The amount that gets into the milk is so tiny that side effects in the baby should not be expected. Mothers have not reported any to us, in many years of use. Certainly the amount the baby gets through the milk is a tiny percentage of what babies would get if being treated for spitting up.

Are there long term concerns about the use of domperidone?
The manufacturer states in its literature that chronic treatment with domperidone in rodents has resulted in increased numbers of breast tumors in the rodents. The literature goes on to state that this has never been documented in humans. Note that toxicity studies of medication usually require treatment with huge doses over periods of time involving most or all of the animal's lifetime. Note also that not breastfeeding increases the risk of breast cancer, and breast cancer risk decreases the longer you breastfeed.

Using Domperidone
Generally, we start domperidone at 20 milligrammes (two 10 mg tablets) four times a day. Printouts from the pharmacy often suggest taking domperidone 30 minutes before eating, but that is because of its use for digestive intolerance. You can take the domperidone about every 6 hours, when it is convenient (there is no need to wake up to keep to a 6 hour schedule - it does not make any difference). Most mothers take the domperidone for 3 to 8 weeks. Mothers who are nursing adopted babies may have to take the drug much longer.

After starting domperidone, it may take 3 or 4 days before you notice any effect, though sometimes mothers notice an effect within 24 hours. It appears to take 2 to 3 weeks to get a maximum effect.

After you have used domperidone for two weeks, we ask you to call (416) 813-5757 (option 3) and ask for a return call. Based on your information, a decision will be made what to do next. If you have unexplained symptoms at any time call the same number immediately.



This article may be copied and distributed
without further permission



About the Author
JACK NEWMAN graduated from the University of Toronto medical school as a pediatrician in 1970. He started the first hospital-based breastfeeding clinic in Canada in 1984 at Toronto's Hospital for Sick Children. He has been a consultant with UNICEF for the Baby Friendly Hospital Initiative in Africa, and has published articles on the subject of breastfeeding in Scientific American and several medical journals. Dr. Newman has practiced as a physician in Canada, New Zealand, and South Africa.
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#2 of 9 Old 03-21-2002, 12:52 AM
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thank you for this Krista, so it has to be prescribed yes? And if you were to just ask for it would they give it to you? you think?
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#3 of 9 Old 03-21-2002, 03:33 PM - Thead Starter
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It sounds like it gal! Let me know what your dr says if you talk to him/her about this, i would be very interested in hearing what she says about it.
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#4 of 9 Old 03-21-2002, 03:36 PM
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I spoke with a LC about it, and she said they only use it as a last resort because it has some nasty side effects. She didn't go into detail, but I'd definitely research it before taking it!
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#5 of 9 Old 03-21-2002, 08:12 PM - Thead Starter
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Here is some more info. that i found on it. I put the side effects in bold for you

Domperidone

Introduction

Domperidone (Motilium™) is a drug which has, as a side effect, the increased production of the hormone prolactin. Prolactin is the hormone which stimulates the cells in the mother's breast to produce milk. Domperidone increases prolactin secretion indirectly, by interfering with the action of dopamine. One of the actions of dopamine is that it decreases the secretion of prolactin by the pituitary gland. Domperidone is generally used for disorders of the gastrointestinal tract (gut) and has not been released in Canada for use as a stimulant for milk production. This does not mean that it cannot be prescribed for this reason, but rather that the manufacturer does not back its use for increasing milk production. It has been used, for several years, in small infants who spit up and lose weight, but it has recently been replaced for this reason by a newer drug called cisapride (Prepulsid™). Domperidone's ability to increase milk production has been recognized since it first became available. Another, related, but older medication, metoclopramide (Maxeran™), is also known to increase milk production, but it has frequent side effects which have made its use for many nursing mothers unacceptable (fatigue, irritability, depression). Domperidone has many fewer side effects because it does not enter the brain tissue in significant amounts (does not pass the blood-brain barrier).

When is it appropriate to use domperidone?

Domperidone must never be used as the first approach to correcting breastfeeding difficulties. Domperidone is not a cure for all things. It must not be used unless all other factors which may result in insufficient milk supply have been dealt with first. These include:

1. correcting the baby's latch so that the baby can obtain as efficiently as possible the milk which the mother has available. Correcting the latch may be all that is necessary to change a situation of "not enough milk" to one of "plenty of milk".

2. using breast compression to increase the intake of milk (handout #15 Breast Compression).

3. using milk expression after feedings to increase the supply.

4. correcting sucking problems, stopping the use of artificial nipples (handout #5, Using a Lactation Aid, and #8, Finger Feeding) and other stratagems.

Using domperidone for increasing milk production

Domperidone works particularly well to increase milk production under the following circumstances:

it has frequently been noted that a mother who is pumping milk for a sick or premature baby in hospital has a decrease in the amount she pumps around 4 or 5 weeks after the baby is born. The reasons for this are likely many, but domperidone generally brings the amount of milk pumped back to where it was or even to higher levels.
when a mother has a decrease in milk supply, often associated with the use of birth control pills (avoid œstrogen containing birth control pills while breastfeeding), or on occasion for no obvious reason when the baby is 3 or 4 months old, domperidone will often bring the supply back to normal.

Domperidone still works, but often less dramatically when:

the mother is pumping for a sick or premature baby but has not managed to develop a full milk supply.
the mother is trying to develop a full milk supply while nursing an adopted baby.
the mother is trying to wean the baby from supplements.

Side effects of domperidone

As with all medications, side effects are possible, and many have been reported with domperidone (textbooks often list any side effect ever reported, but symptoms reported are not necessarily due to the drug a person is taking). There is no such thing as a 100% safe drug. However, our clinical experience has been that side effects in the mother are extremely uncommon, except for increasing milk supply. Some side effects which mothers we have treated have reported (very uncommonly, incidentally):

dry mouth
headache which disappeared when the dose was reduced
abdominal cramps

The amount that gets into the milk is so tiny that side effects in the baby should not be expected. Mothers have not reported any to us, in many years of use. Certainly the amount the baby gets through the milk is a tiny percentage of what babies would get if being treated for spitting up.


Are there long term concerns about the use of domperidone?

The manufacturer states in its literature that chronic treatment with domperidone in rodents has resulted in increased numbers of breast tumours in the rodents. The literature goes on to state that this has never been documented in humans. Note that toxicity studies of medication usually require treatment with huge doses over periods of time involving most or all of the animal's lifetime. Note also that not breastfeeding increases the risk of breast cancer, and breast cancer risk decreases the longer you breastfeed.

Using Domperidone

Generally, we start domperidone at 20 milligrammes (two 10 mg tablets) four times a day. Printouts from the pharmacy often suggest taking domperidone 30 minutes before eating, but that is because of its use for digestive intolerance. You can take the domperidone about every 6 hours, when it is convenient (there is no need to wake up to keep to a 6 hour schedule—it does not make any difference). Most mothers take the domperidone for 3 to 8 weeks. Mothers who are nursing adopted babies may have to take the drug much longer.

After starting domperidone, it may take three or four days before you notice any effect, though sometimes mothers notice an effect within 24 hours. It appears to take two to three weeks to get a maximum effect.

After you have used domperidone for two weeks, we ask you to call (416) 813-5757 (option 3) and ask for a return call. Based on your information, a decision will be made what to do next. If you have unexplained symptoms at any time call the same number immediately.

Handout #19. Domperidone. January 1998

Written by Jack Newman, MD, FRCPC

May be copied and distributed without further permission
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#6 of 9 Old 03-21-2002, 08:21 PM
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Well that certainly doesn't sound so nasty. Wonder what her hesitation was about? Is this the only drug prescribed for increasing milk that you've heard about?
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#7 of 9 Old 03-21-2002, 08:25 PM - Thead Starter
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Since i have never had a problem with my milk supply, yes, this is the first drug that i have ever heard of. I am sure that their must be some others. I can try to look up some more for you if you would like me to.
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#8 of 9 Old 03-21-2002, 09:14 PM
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That's not necessary. I was just wondering what the awful side effects they were referring to were. I thought that maybe there was a different drug that she was thinking about. This doesn't sound bad at all ...
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#9 of 9 Old 03-22-2002, 03:08 AM
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thank you but nevermind. *sigh* I will explain in another post.
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